It is essential to make openings in structural concrete elements to accommodate mechanical and electrical needs. To study the effect of these openings on the performance of reinforced concrete (RC) elements, a numerical investigation was performed and validated using previous experimental work. The effect of the position and dimension of the opening and the beam length on the response of the beams, loads capacities, and failure modes was studied. The simulated RC beams showed different responses, loads capacities, and failure modes depending on the position and dimension of the opening. The transversal near support opening (TNSH) and longitudinal holes (LH) showed lower effects on the load capacities of the beams than the transversal near center opening (TNCH). The supreme reduction percentages of the load capacity (μu%) for beams with TNCH and TNSH were 37.21% and 30.34%, respectively (opening size = 150  150 mm2). In addition, the maximum μu% for beam with LH was 17.82% (opening size = 25% of the beam size). The TNSH with a width of less than 18.18% of the beam shear span (550 mm) had trivial effects on the beam’s load capacities (the maximum μu% = 1.26%). Although the beams with combined LH and TNCH or LH and TNSH showed different failure modes, they experienced nearly the same load reductions. Moreover, the length of the beam (solid or hollow) had a great effect on its failure mode and load capacity. Finally, equations were proposed and validated to calculate the yield load and post-cracking deflection for the concrete beams with a longitudinal opening.