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EFFICACY OF CONTRAST-ENHANCED FDG PET/CT IN PATIENTS AWAITING LIVER TRANSPLANTATION WITH RISING ALPHA-FETOPROTEIN AFTER BRIDGE THERAPY OF HEPATOCELLULAR CARCINOMA
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Abdelaziz Elsayed Mohamd
Staff Zu Site
Abstract In Staff Site
Journal:
European Radiology Springer
Volume:
Keywords :
EFFICACY , CONTRAST-ENHANCED , PET/CT , PATIENTS AWAITING LIVER
Abstract:
Objective To assess the diagnostic accuracy and illustrate positive findings of contrast-enhanced fluorine-18 fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) image in patients awaiting liver transplantation (LT) with rising alpha-fetoprotein (AFP) after bridge therapy of hepatocellular carcinoma (HCC). Materials and methods This prospective study included 100 patients who were waiting for LT and who previously underwent locoregional therapy (LRT) of HCC. These patients had rising AFP levels on a routine follow-up examination awaiting LT. All patients underwent a contrast-enhanced 18F-FDG PET/CT examination. We calculated for each patient the maximum standardised uptake value (SUVmax) of the tumour and the ratio of the tumoral SUVmax to the normal-liver SUVmax. The diagnostic accuracy and positive contrast-enhanced findings of 18F-FDG PET/CTwere established by histopathology and clinical and imaging follow-up as the reference standards. Results Contrast-enhanced 18F-FDG PET/CT detected tumour relapse in 78 patients (13 patients had intrahepatic lesions, 10 patients had extrahepatic metastases and 55 patients with combined lesions). The sensitivity, specificity and accuracy values of contrast-enhanced 18F-FDG PET/CT examination in the detection of HCC recurrence were 92.8%, 94.1% and 93%, respectively. A significant correlation was found between the AFP level and SUVmax ratio (r = 0.2283; p = 0.0224). The best threshold for 18F-FDG PET positivity was >1.21. Conclusion Contrast-enhanced 18F-FDG PET/CT is a valuable tool for the detection of intrahepatic HCC recurrence or extrahe- patic metastasis following rising AFP levels after LRT of HCC, and should be incorporated during routine workup awaiting LT.
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Ahmed Abdelaziz Elsayed Mohamd, "Efficiency of diffusion weighted magnetic resonance in differentiation between benign and malignant endometrial lesions", science direct, 2017
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Ahmed Abdelaziz Elsayed Mohamd, "CLINICAL USEFULNESS OF PET-CT IN STAGING, EVALUATION OF TREATMENT RESPONSE AND RESTAGING OF THORACIC LYMPHOMA", science direct, 2017
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Ahmed Abdelaziz Elsayed Mohamd, "Diagnostic efficacy of the Liver Imaging-Reporting and Data System (LI-RADS) with CT imaging in categorising small nodules (10e20 mm) detected in the cirrhotic liver at screening ultrasound", science direct, 2017
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Ahmed Abdelaziz Elsayed Mohamd, "ROLE OF 3D-CT IN EVALUATING EXTENSOR TENDON RUPTURE IN RHEUMATOID WRIST", Wolters Kluwer, 2012
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Ahmed Abdelaziz Elsayed Mohamd, "Assessment of Inferior Vena Cava Abnormalities with Multi Detector Computed Tomography", كلية الطب- جامعة القاهرة, 2016
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