Background: Cyberbullying perpetration and victimization became a common phenomenon with the development of Information and Communication Technologies (ICT). The prevalence rate of cyberbullying among adolescents, in general, was ranged between 10-40 %. The study aimed to explore the moderator effects of Emotional Intelligence and family incivility on cyberbullying among adolescent students at Zagazig University. This descriptive cross-sectional study was conducted on 1500 Egyptian students from theoretical and practical faculties. Data were collected through four tools: Socio-demographic data sheet, the European Cyberbullying Intervention Project Questionnaire, the Family Incivility Scale, and Schutte Self Report Emotional Intelligence Scale. The results indicated that more than one-fourth of adolescents were bully-victims (26.3%), while 15.8% were bully perpetrators. Cyber-bully victims increased with cyber-bully perpetrators, high family incivility associated with lower Emotional Intelligence (p<0.001). Cyberbullying perpetrators and victims had negative correlation with Emotional Intelligence and positive correlation with family incivility. The study concluded that the cyber-bully perpetrators prevalence was less than cyber-bully victims among the university students. As well as, family incivility, and Emotional Intelligence have moderating effects on cyberbullying victims and perpetrators. The study recommended psychosocial intervention programs directed to adolescent students and their parents to prevent cyberbullying, avoid family incivility and enhancement of Emotional Intelligence among adolescents.