Background: Depression and loneliness are common mental health problems among elderly people and can result from complex interactions of risk factors. Aim of the study: To evaluate the effect of nursing intervention program on depressive symptoms and feeling of loneliness among elderly people at Kafr-ElSheikh City in Egypt. Design: A quasi-experimental design. Setting: The study was carried out at El-Safa Geriatric social club in Kafr-Elsheikh City, Egypt. Sample: A purposive sample of 50 elderly. Tools: Three tools were used in the present study; the first tool was a structured interview questionnaire consisted of two parts; the second tool was Beck Depression Inventory-II (BDI-II) and the third tool was UCLA Loneliness Scale Version 3. Results: The results revealed post-intervention statistically significant reductions in the score of depressive symptoms (P=0.02) and feeling of loneliness (P=0.01). The results also revealed the presence of a highly positive statistically significant correlation between depression and loneliness among the studied elderly (r=0.86). Conclusion: The study intervention was effective on reducing depressive symptoms and feeling of loneliness among the studied elderly. Recommendations: Applying the study intervention program for more improvements and other cognitive- behavioral therapies to decrease the risk of depression and loneliness among the studied elderly, with counseling clinics in the geriatric social clubs. Enhancement social interaction and establishing linkages with other governmental institutions.