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Differential modulatory effect of Epigallocatechin-3-gallate in suppression of tumor proliferation
Faculty
Science
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Sayed Ahmed Abdelwahed Ali Algazeery
Staff Zu Site
Abstract In Staff Site
Journal:
Biomedical & Pharmacology Journal Oriental Scientific Publishing Company
Volume:
Keywords :
Differential modulatory effect , Epigallocatechin-3-gallate , suppression , tumor
Abstract:
Despite the remarkable progress in selecting the chemotherapeutic drugs, most are expensive and associated with many adverse effects targeting both cancer and normal cells. The using of polyphenols as natural materials for chemoprevention is considered a promising approach in reducing the tumor proliferation. This study aims to investigate whether a difference between the use of green tea and its component Epigallocatechin-gallate (EGCG) in treatment and protection against tumor. Sixty female Swiss albino mice weighted 20–22 g divided into 6 groups (n=10). The tumor suppression of green tea and EGCG was mirrored by evaluating their antioxidant and the anti-inflammatory effect on tumor markers and DNA integrity. Our results showed that the administration of EGCG showed a significant elevation of both antioxidants and anti-inflammatory markers in serum of EAC-bearing animals and revealed its high curative power to protect than treat tumor growth. Moreover, genomic DNA fragmentations assay present EGCG as a modulatory agent in keeping genome integrity. The administration of green tea and its major constituent EGCG showed a significant a potent protective role in suppressing tumor proliferation than its use in treatment due to its antioxidant and anti-inflammatory effect and maintaining the integrity of underlying genomic DNA that make it a strong barrier which arrest the process of oncogensis.
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Ahmed Sayed Ahmed Abdelwahed Ali Algazeery, "Drosophila Yemanuclein associates with the cohesin and synaptonemal complexes", Journal of Cell Science, 2014
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Ahmed Sayed Ahmed Abdelwahed Ali Algazeery, "Evaluation of the curative and protective role of fresh chicory juice in treatment of hepatic fibrosis in male albino rats", Oriental Scientific Publishing Company, 2021
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Ahmed Sayed Ahmed Abdelwahed Ali Algazeery, "Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus", www.plosgenetics.org, 2013
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Ahmed Sayed Ahmed Abdelwahed Ali Algazeery, "Vitamin D Receptor Polymorphism and Prostate Cancer Prognosis", S. Karger AG , Switzerland, 2022
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Samir Abdullah Taha, "Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaea natalensis snails", كلية العلوم, 2013
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Iman Hassan Mohammed Sheikh, "Light and scanning electron microscopic study of the dorsal lingual papillae of the rat Arvicanthis niloticus (Muridae, Rodentia)", Elsevier, 2012
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