Introduction: Cardiovascular diseases (CVD) are the world's most common cause of death. The Framingham risk score (FRS) is the most commonly used method for CVD risk assessment. Low risk individuals have 10% or less coronary heart diseases (CHD) risk at 10 years, 10-20% intermediate risk and 20% or more high risk. Aim of the work: To estimate the risk of developing cardiovascular diseases over next ten years among the administrative staff at Zagazig University, Egypt. Material and Methods: A structured questionnaire was used to get data about socio-demographic characteristics, anthropometric measurements were done, laboratory investigations to measure fasting and post brandial blood sugar and lipid profile. The Framingham risk score (FRS) was calculated by using information on age, gender, smoking, diabetes mellitus (DM), systolic blood pressure, treatment for hypertension, and total blood cholesterol, high-density lipoprotein levels for every subject. Results: About 55% of the studied sample were male and (44.8%) were females, the overall prevalence of systolic hypertension was 45.7%, 36.2% with family history of CVD, 25% were physically active majority of them were male,21.5% was diabetic, 63.7% have high blood cholesterol,55.1% have central obesity,68.1% overweight or obese. FRS mean for males were higher as compared to females (14.3±7.1 and11.9±5.8 respectively). Participants with high CVR risk are mainly inactive, smokers, with positive family history, diabetics, hypertensive, with high blood cholesterol level, high density lipoprotein and with central obesity A statistically significant positive correlation was observed between FRS and age, cholesterol, systolic blood pressure, blood glucose, weight ,waist circumference and BMI . Conclusion: About 42% of our studied subjects were at low anticipated 10-year CVD risk, 30% had moderate risk, and 28% of them were at high risk. The most significant risk factors were male gender, smoking, physical inactivity, hypertension, DM, obesity, abdominal obesity, high levels of total cholesterol and low HDL-cholesterol level in addition to positive family history . CVD is a preventable public health issue, most of its risk factors are modifiable.