Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Faculty Specific Education Year: 2022
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Egyptian Journal of Chemistry NIDOC. Volume:
Keywords : Heterocyclization , Biological Evaluation , Malonic Hydrazide; Novel    
Abstract:
Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.
   
     
 
       

Author Related Publications

  • Yasser Abdelaal Sleim Elewa, "Antibacterial and antibiofilm effects of silver nanoparticles against the uropathogen Escherichia coli U12", science direct, 2022 More
  • Yasser Abdelaal Sleim Elewa, "Role of Enaminonitriles in Heterocyclic Synthesis: Synthesis of Some New Aminothiazole Derivatives against Prostate Carcinoma", Taylor & Francis, 2022 More
  • Yasser Abdelaal Sleim Elewa, "Two new pentacyclic triterpenoids from the roots of Achellia Fragrantissima F. and their biological activity", Ukrainica Bioorganica Acta, 2011 More
  • Yasser Abdelaal Sleim Elewa, "Anti-Inflammatory New Coumarin from the Ammi majus L.", Organic and Medicinal Chemistry Letters, 2012 More
  • Yasser Abdelaal Sleim Elewa, "Fremy’s Salt-Mediated Oxidative Addition. A New Approach in the Total Synthesis of Naturally Dipetalolactone and Its Immunomodulatory Activity", Molecules, 2013 More

Department Related Publications

  • Safynaz Samir Mohamed Abd ELmasoud, "Effect of Using Mind Maps & Amalgamation of Tradition Motifs for Developing Students' Skills to Create Contemporary Designs Proper for Hotels and Tourist Villages' Upholstery", المؤتمر الدولي الثاني "التنمية المستدامة للمجتمعات بالوطن العربي" ( دور الثقافة والتراث والصناعات الإبداعية والسياحية والعلوم التطبيقية في التنمية ال, 2017 More
  • Safynaz Samir Mohamed Abd ELmasoud, "Effect of variation of sewing method and types of zippers on the functional performance properties of clothes", المؤتمر العلمي السنوي (العربي الثالث عشر – الدولي العاشر) بعنوان " التعليم النوعي في مصر والوطن العربي في ضوء استراتيجيات التنمية المستدامة" كلية ال, 2018 More
  • Ghada Abdelfattah Abdelrahman Elsayed, "إمكانية صباغة أقمشة تريكو اللحمة ببعض مستخلصات الصبغات الطبيعية الآمنة بيئيا لاستخدامها في صناعة عرائس الأطفال", مجلة كلية الاقتصاد المنزلي - جامعة المنوفية مجلد(22) العدد(4) 2012 م ISSN) 2578-1110)., 2012 More
  • ahdab abdou mohamed elmaadawy, "Effect of Low Fat Yoghurt Supplemented With Garden Cress Seeds Powder on Hypercholesterolemic Rats.", Egyptian Nutrition Society, 2019 More
Tweet