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Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines
Faculty
Specific Education
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Yasser Abdelaal Sleim Elewa
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Chemistry NIDOC.
Volume:
Keywords :
Heterocyclization , Biological Evaluation , Malonic Hydrazide; Novel
Abstract:
Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.
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Yasser Abdelaal Sleim Elewa, "Role of Enaminonitriles in Heterocyclic Synthesis: Synthesis of Some New Aminothiazole Derivatives against Prostate Carcinoma", Taylor & Francis, 2022
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Yasser Abdelaal Sleim Elewa, "Two new pentacyclic triterpenoids from the roots of Achellia Fragrantissima F. and their biological activity", Ukrainica Bioorganica Acta, 2011
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Yasser Abdelaal Sleim Elewa, "Anti-Inflammatory New Coumarin from the Ammi majus L.", Organic and Medicinal Chemistry Letters, 2012
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Yasser Abdelaal Sleim Elewa, "Fremy’s Salt-Mediated Oxidative Addition. A New Approach in the Total Synthesis of Naturally Dipetalolactone and Its Immunomodulatory Activity", Molecules, 2013
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Department Related Publications
Safynaz Samir Mohamed Abd ELmasoud, "Effect of Using Mind Maps & Amalgamation of Tradition Motifs for Developing Students' Skills to Create Contemporary Designs Proper for Hotels and Tourist Villages' Upholstery", المؤتمر الدولي الثاني "التنمية المستدامة للمجتمعات بالوطن العربي" ( دور الثقافة والتراث والصناعات الإبداعية والسياحية والعلوم التطبيقية في التنمية ال, 2017
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Safynaz Samir Mohamed Abd ELmasoud, "Effect of variation of sewing method and types of zippers on the functional performance properties of clothes", المؤتمر العلمي السنوي (العربي الثالث عشر – الدولي العاشر) بعنوان " التعليم النوعي في مصر والوطن العربي في ضوء استراتيجيات التنمية المستدامة" كلية ال, 2018
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Ghada Abdelfattah Abdelrahman Elsayed, "إمكانية صباغة أقمشة تريكو اللحمة ببعض مستخلصات الصبغات الطبيعية الآمنة بيئيا لاستخدامها في صناعة عرائس الأطفال", مجلة كلية الاقتصاد المنزلي - جامعة المنوفية مجلد(22) العدد(4) 2012 م ISSN) 2578-1110)., 2012
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ahdab abdou mohamed elmaadawy, "Effect of Low Fat Yoghurt Supplemented With Garden Cress Seeds Powder on Hypercholesterolemic Rats.", Egyptian Nutrition Society, 2019
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