Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Faculty Specific Education Year: 2022
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Egyptian Journal of Chemistry NIDOC. Volume:
Keywords : Heterocyclization , Biological Evaluation , Malonic Hydrazide; Novel    
Abstract:
Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.
   
     
 
       

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