Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Faculty Specific Education Year: 2022
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Egyptian Journal of Chemistry NIDOC. Volume:
Keywords : Heterocyclization , Biological Evaluation , Malonic Hydrazide; Novel    
Abstract:
Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.
   
     
 
       

Author Related Publications

  • Yasser Abdelaal Sleim Elewa, "Antibacterial and antibiofilm effects of silver nanoparticles against the uropathogen Escherichia coli U12", science direct, 2022 More
  • Yasser Abdelaal Sleim Elewa, "Role of Enaminonitriles in Heterocyclic Synthesis: Synthesis of Some New Aminothiazole Derivatives against Prostate Carcinoma", Taylor & Francis, 2022 More
  • Yasser Abdelaal Sleim Elewa, "Two new pentacyclic triterpenoids from the roots of Achellia Fragrantissima F. and their biological activity", Ukrainica Bioorganica Acta, 2011 More
  • Yasser Abdelaal Sleim Elewa, "Anti-Inflammatory New Coumarin from the Ammi majus L.", Organic and Medicinal Chemistry Letters, 2012 More
  • Yasser Abdelaal Sleim Elewa, "Fremy’s Salt-Mediated Oxidative Addition. A New Approach in the Total Synthesis of Naturally Dipetalolactone and Its Immunomodulatory Activity", Molecules, 2013 More

Department Related Publications

  • Rehab Mohamed Ali Ismaiel, "تحقيق أفضل الخواص الوظيفية لأقمشة الملابس الكتانية والمخلوطة المجهزة بمواد صديقة للبيئة (دكتوراة لم تناقش بعد)", لايوجد, 1900 More
  • Ghada Abdelfattah Abdelrahman Elsayed, "THE POSSIBILITY OF MERGENCE BETWEEN BUTTONS AND REMNANTS OF SYNTHETIC LEATHER USING PLANT DECORATIONS TO ACHIEVE FUNCTIONAL PERFORMANCE, AESTHETIC AND ECONOMIC PROPERTIES FOR LADIES OUT WEAR", بالمجلة العلمية علوم وفنون –دراسات وبحوث –, 2013 More
  • Ghada Abdelfattah Abdelrahman Elsayed, "إثراء القيمة الجمالية لملابس الأطفال (المرحلة الوسطي) باستخدام التقنيات المختلفة", مجلة كلية التربية النوعية - جامعة المنصورة العدد(26) ص448-472يوليو 2012 م ., 2012 More
  • Ghada Abdelfattah Abdelrahman Elsayed, "دراسة تأثير المعالجة البنائية لخاصية الالتواء لأقمشة السنجل جيرسى المنتجة على ماكينات تريكو اللحمة المستطيلة", المؤتمر الدولي الأول لكلية التربية النوعية –جامعة كفر الشيخ في الفترة 22-24نوفمبر 2011م., 2011 More
  • Akmal Shawky Gaballa, "Spectroscopic studies on [(DD18C6H2)(HPA)2](PA)2 and [(DD18C6H2)(DDQ)2](DDQH)2 formed in the reaction of N ,N -dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane with HPA and DDQ", Spectrochim. Acta A, 2005 More
Tweet