A New Approach for Synthesis of 2-Thioxocytosine-5-carbonitrile as Antimicrobial Agents

Faculty Science Year: 2022
Type of Publication: ZU Hosted Pages: 1806–1813
Authors:
Ahmed Heussein Mostafa
Journal: ٌRussian Journal of General Chemistry ٍSpringer Volume: 92
Keywords : , , Approach , Synthesis , 2-Thioxocytosine-5-carbonitrile as Antimicrobial Agents    
Abstract:
A highly efficient synthetic methodology for the preparation of 2-thioxocytosine was achieved by the nucleophilic addition of thiourea to α-cyanocinnamonitrile followed by intramolecular cyclization. The reaction smoothly proceeds in the presence of K2CO3-NPs as mild basic catalyst with yield 85%. The product was annulated to new imidazo[1,2-c]pyrimidine derivatives. Besides, Schiff base and acylated pyrimidine derivatives were synthesized via condensation or acylation with triethyl orthoformate, formic acid, maleic anhydride, benzoyl chloride or acetic anhydride
    
     
 
       

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