During the winter seasons of 2017/2018 and 2018/2019, this study was carried out at El-Khattara Experimental Farm, Faculty of Agriculture, Zagazig University, Sharkia Governorate (Egypt), to investigate the effects of N, P, and K rates as well as foliar spray with Micro plant 19 compound (MP19) on growth, yield and quality of spinach plants. The treatments were as follows: Fertilizing with 100 % NPK of recommended rate (RR),100% NPK of RR+ spraying with (MP19), 50 % N+75 % P+50 % K of RR + (MP19), 50 % N+100 % P+50 % K of RR + (MP19), 50 % N+125 % P+50 % K of RR + (MP19) and 50 % N+150 % P+50 % K of RR + (MP19). Fertilizing spinach plants with 100 % NPK+ spraying with (MP19) resulted in a significant increase in plant height, number of leaves/plants, fresh and dry weight/plant, in addition, nitrogen, phosphorus and potassium uptake by leaves of plant and total yield per feddan. Whereas, fertilizing spinach plants with 50 % N+150 % P+50% K of RR and spraying with (MP19) reduced both of nitrate and oxalate concentration in leaves.