Background: Post ACL reconstruction knee sepsis is rare but disastrous. This complication should be treated as an emergency. Repeated arthroscopic debridement and lavage is considered the main line of treatment by most authors. Another promising treatment option is single arthroscopic debridement followed by repeated suction irrigation Patients and Methods: Seventeen infected cases of 750 cases had anatomical ACL reconstruction with hamstring autograft was managed with single arthroscopic debridement followed by repeated suction irrigation. Continuous patient monitoring both clinical and radiological during the irrigation period was done was done for all cases. Results: During the period of irrigation clinical and laboratory parameters showed rapid improvement. Later only one case had recurrent infection. The mean Lysol score at the final follow up was 79.7. The graft was retained in 16 cases and discarded in one cases. Conclusion: This line of treatment is successful compared with repeated arthroscopic debridement but with less cost, better tolerated by patients and avoids repeated surgical trauma.