Abstract: Honey has been used as a traditional remedyfor various health benefits. This study investigated thepotential of honey against the onset of autoimmune diabetes and its associated secondary complications in type1 diabetic (T1D) experimental animals. Autoimmune diabetes was induced in Sprague Dawley rats, and at the sametime, the rats were treated with honey or metformin. SandwichELISAs wereused to estimate blood glucose, hemoglobin A1C(HbA1c), total cholesterol, and triglycerides. Histopathologicalexaminations determined the T1D-induced lesions on kidneys,pancreas, cornea, and retina. Treatment of rats with honeyduring the course of T1D induction showed a significantreduction in fasting-blood-glucose and HbA1c (p < 0.01),and total lipid profile was also improved (p < 0.05). Notonly these, but honey also reduced the T1D-induced lesionsin the kidney, pancreas, and cornea/retina (p < 0.05). Metformin showed similar effects and was used as a positive control. In conclusion, honey showed therapeutic potential against the onset ofreduces blood glucose/HbA1c and improves the lipid profile by reducingtheplasma levels of total cholesterol,low-density lipoproteins (LDL), very low-density lipoprotein (VLDL), and triglycerides. Moreover, it also showedprotective potential against the development of diabeticnephropathy, pancreatitis, and retinopathy. Keywords: type1 diabetes, diabetic rats, honey, blood sugar, lipid profile, histopathology