The roleofneuralprecursorcell-expresseddevelopmentally down-regulated protein9inpredictingbacillusCalmette-Guerin response innonmuscleinvasivebladdercancer

Faculty Medicine Year: 2018
Type of Publication: ZU Hosted Pages: 1078-1439
Authors:
Eslam Mohyeldeen
Journal: Urologic Oncology:Seminars and Original Investigations Elsevier Volume: 873-2496
Keywords : , roleofneuralprecursorcell-expresseddevelopmentally down-regulated protein9inpredictingbacillusCalmette-Guerin response innonmuscleinvasivebladdercancer    
Abstract:
Abstract Objective: To reportthesensitivityandspecificity ofneuralprecursorcell-expresseddevelopmentallydown-regulatedprotein9 (NEDD9) proteinhighexpressioninpredictingBCGresponseanditseffectonrecurrenceorprogressionfreesurvivals. Patients andmethods: Between May2014andApril2017,aprospectivecohortstudywasconductedon105patientswithintermediate or high-risknonmuscleinvasivebladdercancer.Immunohistochemicalstainingwithmousemonoclonalanti-NEDD9antibodywasdone. Examination oftheslideswasdonetodetectNEDD9cytoplasmicexpression.IntravesicalinductionbacillusCalmette-Guerin(BCG) instillation therapywasstartedforallpatients2to4weeksafterendoscopywithonceweeklyinstillationfor6weeks.Intravesical maintenance BCGinstillationwasthencontinuedevery3monthsforatleast1year.Followupwithcystoscopyevery3monthsfor2years and every6monthsafterthat. Results: The meanage ± SD ofthepatientswas57 ± 4.5 years.Themedianfollow-upperiodwas25(12–36) months.NEDD9protein was highlyexpressedin61(58.1%)patients,whereaslowexpressionwasin44(41.9%)patients.Sensitivityandspecificity ofNEDD9high expression inpredictingrecurrencewere83.6%and64.2%,respectively.Itssensitivityandspecificity inpredictingprogressiontomuscle invasion ordistantmetastaseswere91.3%and51.2%,respectively.Itssensitivityandspecificity inpredictingcompleteresponsetoBCG therapy were84.1%and80.9%.Kaplan-Meiertestshowedhighlysignificant difference(P o 0.0001) insurvivalwithoutrecurrenceor progression betweenpatientsshowinghighexpressionandthoseshowinglowexpression. Conclusion: NEDD9 proteintissuemarkercouldbeusedasapredictivemarkerforBCGresponseinnonmuscleinvasivebladdercancer with reasonablesensitivityandspecificity.
    
     
 
       

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