The presence of attention deficit hyperactive disorder (ADHD) cause great impairment in social and professional activates as well as in the quality of life (QOL) and increase level of parental stress. Objective: This study aimed to compare the QOL, self-competence and self-liking among the caregivers of ADHD and non-ADHD children. Method: A descriptive cross-sectional study was conducted on 216 of caregivers, divided into two groups of caregivers of children with and without ADHD. Setting: This study was conducted in the Elsinbellawin City at dakahlia governorate in Egypt. Tools used were sociodemographic data sheet, The WHO Quality of Life Scale-Bref (WHOQOL-Bref) and self-liking/ self-competence Scale. Results: Our results showed that all QOL dimensions of the caregivers of ADHD children were markedly deteriorated, if compared to those of non-ADHD children and two third of caregivers of ADHD children suffered from poor level quality of life (QOL) . Caregivers of non-ADHD children had fair level of self-competence but a good level of self-liking. Caregiver of ADHD children who had no work nor history of medical diseases has fair level of QOL and self-competence but a good level of self-liking. Conclusions: We found that caregiver of ADHD children have fair levels of QOL, self-liking and self-competence, if compared to those of non-ADHD children. There is statistically significant correlations between QOL, self-competence, and self-liking among both caregivers of both non-ADHD children and ADHD children.