Background: Acrylamide (ACR) is an essential chemical which is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives and polishes; it is known as possible carcinogenic compound. French fries, commercially common chips and all carbohydrate containing diet are rich in acrylamide. In this study when Acrylamide is taken into the body, we investigated its toxic effect on body organs and investigated the protective role of selenium. Aim: The aim of this work is to detect acrylamide effects on liver and kidney of adult male albino rats and assess the protective role of selenium. Material and methods: Acrylamide was administrated orally at dose of (15 mg/kg body weight) (1/10 LD 50) daily for 8 weeks. Biochemical parameters in serum were studied: aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), total proteins, Albumin, Globulin, urea, creatinine, and uric acid. Liver and kidneys will be examined by light microscope to evaluate histopathological changes. Tissue malondialdehyde (MDA) was done. Results: The results after being statistically analyzed and tabulated revealed that oral Acrylamide administration showed a highly significant (P<0.001) elevation in aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), a highly significant (P<0.001) decrease in serum total protein, albumin, globulin and highly significant (P<0.001) decrease in serum urea, creatinine, and uric acid levels comparing to control group. Light microscope examination of the hepatic tissue in acrylamide treated group showed obvious congestion associated with widespread marked vacuolar degeneration and kidneys showed marked congestion, marked hydropic degeneration of tubular epithelium and focal prominent tubular necrosis. There was a highly significant (P<0.001) increase in malondialdehyde level in acrylamide treated group comparing to control group. Selenium administration in addition to acrylamide showed significant decrease in aspartate-aminotransferase, alanine-aminotransferase, significant elevation in serum total proteins, albumin, globulin and significant increase in serum urea, creatinine, and uric acid levels comparing to acrylamide treated group. There was significant decrease in malondialdehyde level in acrylamide+sodium selenite treated group comparing to acrylamide treated group Conclusion: It was established that oral acrylamide administration induced destructive effects in the liver and kidneys, and selenium administration during exposure to acrylamide offers protection against its damaging effect. Recommendations: Acrylamide caused a potential risk for a series of crucial damage, So, Limitation of using acrylamide in our food and screening of its harmful effects occupationally is very important. Also, raising the awareness among population about its hazardous effects.