Background: Rheumatic diseases are among the oldest diseases recognized. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common rheumatic diseases, accounting for a large percentage of disability worldwide. Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the sacroiliac joints and spine, most commonly in young people. Acceptance of chronic pain has become an important concept in understanding and predicting that chronic pain sufferers can remain engaged with meaningful aspects of life. Chronic Pain Acceptance Questionnaire (CPAQ) has been validated with good reliability and validity in many countries to assess the level of pain acceptance in rheumatic disease patients. Aim of the study: To test the reliability and validity of translated Arabic version of Chronic Pain Acceptance questionnaire in rheumatic diseases (RA, AS and OA) and to use this important tool in the management of rheumatic diseases. Subjects and Methods: This cross-sectional study was conducted on 219 rheumatic disease patients divided into 3 groups: 73 Rheumatoid Arthritis (RA) patients, 73 Ankylosing Spondylitis (AS) patients, and 73 Osteoarthritis (OA) patients. Patients attended to the inpatient ward and outpatient clinics of Rheumatology and Rehabilitation Department, Faculty of medicine, Zagazig University hospitals. All patients were subjected to general, local examination, and laboratory investigations. Communication with the CPAQ developer and obtaining permission was done to use the instrument. Translation, cross-cultural adaptation and cross-cultural validation of the CPAQ into the Arabic language were done. A final Arabic version has been produced and used in the study after approval of the developer of all the performed changes. Then testing the reliability and validity of the translated version by a pilot study was done. Results: Regarding Inflammatory Diseases: In the 2-week retest reliability, most of items demonstrated an acceptable internal consistency reliability as well as stability over short term and also acceptable convergent validity. Regarding total score, Pearson correlation, ICC were 0.928 and 0.925 respectively which represented excellent internal consistency reliability as well as stability over short term. Cronbach’s alpha coefficient was found to be, ranged from 0.79, to 0.939 for the 20 items and 0.961 for total score. As the Cronbach’s alpha (0.724, to 0) remained almost the same and none of them was greater than the total scale alpha (0.961), it turned out that the tool has high internal consistency. There was a statistically significant association between pain acceptance and ACR revised. The translated Arabic CPAQ had a 2-factor construct as its original English version. Regarding Degenerative Diseases: most of items also demonstrated an acceptable internal consistency reliability as well as stability over short term. Regarding total score, Pearson correlation, ICC were 0.504 and 0.901 respectively which represented acceptable internal consistency reliability as well as stability over short term. Cronbach’s alpha coefficient was found to be, ranged from 0.765, to 0.949 for the 20 items and 0.906 for total score, it turned out that the tool has high internal consistency. The translated Arabic CPAQ had a 2-factor construct as its original English version. Conclusions: The Arabic version of Chronic Pain Acceptance questionnaire is reliable and valid in rheumatic diseases patients. This measure aids a lot in improving the management strategies for patients with rheumatic diseases as rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis.