Background: Over the last 10 years, social media has become an integral facet of modern society. Self-presentation and body satisfaction are related to social media and its impact on users’ levels of well-being and self-esteem. This study aimed to compare selfie-related concepts (self-esteem and body image) and behaviors (selfie habits and patterns, the motives for using the selfie, and attitude about selfie) between samples of Egyptians and Saudis student nurses. To attain this research aim, a comparative research design study was conducted between 7th of October and 5th of November 2020. This study was conducted in the two countries: Kingdom of Saudi Arabia (KSA) (College of Nursing, Taif University) and Egypt (Faculty of Nursing, Zagazig University). A sample of 300 students was included in two countries: KSA and Egypt. Socio-demographic data sheet, patterns of selfie use scale, self-confidence questionnaire (SCQ), and body image scale. Results: Results revealed that the Egyptian students were higher in number of selfies per day than Saudi students and the majority of Saudi group like to put their selfies on Instagram. Conclusion: The current study deduced that Egyptian students as regard selfie habits and patterns had a higher number of selfies per day than Saudi students, also the majority of the Saudi group as regard selfie habits like to put their selfies on Instagram with a statistically significant difference. As regards the motives for using the selfie, the reasons for taking selfies were significantly higher in Saudi nursing students than in Egyptian students regarding depression and sadness. As well, significantly higher in Egyptian than in Saudi nurse students was related to motivates that their selfies on social media often contain comments or answers, the relationship between the number of selfie-taking and gender was a statistically significant difference between the two genders in both Egyptian and Saudi groups with increasing taking selfie among Egyptian females and Saudi males.