The proportion of the elderly population is increasing with continuous medical progress worldwide. Elderly people often suffer both physiological and psychological illness. Reminiscence program is useful to reduce some psychological problem and assist the elderly to adapt aging process consequences. This study aims to assess the impact of reminiscence program on depressive symptoms, feeling of loneliness and quality of life among elderly people in Egypt. Subjects: study was carried out on 45 institutionalized elderly to assess the tools used clarity and applicability. Setting: Our study was conducted at Dar El-mohafza geriatric home at El-Sharkia governorate. Tools for data collection: A structured questionnaire include: personal data, geriatric depression scale, loneliness scale and quality of life scale was used. Results: Our results revealed that the mean depression score decreased from a pre-intervention level to a post-intervention level and this improvement was highly statistically significant. Also, we observed a statistically insignificant correlation between participants’ scores of depressive symptoms and loneliness score after intervention. Conclusion: Our study concluded that application of reminiscence program for elderly had a positive impact on reducing the depressive symptoms and loneliness level and consequently improving the quality of life among elderly. Recommendation: We recommend that elderly people should be involved in varied reminiscence activities in different caring homes.