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Non-extractive spectrophotometric determination of memantine HCl, clomipramine HCl and fluvoxamine maleate in pure form and in pharmaceutical products by ion-pair complex formation with rose Bengal.
Faculty
Pharmacy
Year:
2020
Type of Publication:
ZU Hosted
Pages:
375-386
Authors:
Rania Adel Sayed Ahmd
Staff Zu Site
Abstract In Staff Site
Journal:
Annales Pharmaceutiques Françaises ScienceDirect
Volume:
Keywords :
Non-extractive spectrophotometric determination , memantine HCl, clomipramine
Abstract:
The objective of this work is to develop a simple, sensitive and non-extractive spectrophotometric method for the determination of memantine HCl (MEM), clomipramine HCl (CLM) and fluvoxamine maleate (FLV). The proposed method was based on the formation of colored ion-pair complexes between the basic nitrogen of the target drugs and rose bengal (RB) dye in a weak acidic medium. The formed complexes were measured at 576 nm for MEM, CLM and at 575 nm for FLV. The reaction conditions were optimized to obtain the maximum color intensity. Beer's law was obeyed in the range of 2–20, 1–16 and 6–30 μg/mL for MEM, CLM and FLV, respectively. The limit of detection (LOD) was 0.476, 0.185, 0.806 and the limit of quantitation (LOQ) was 1.443, 0.559 and 2.443 for MEM, CLM and FLV, respectively. The composition ratio of the ion-pair complexes was found to be 1:1 as determined by Job's method. Conclusion The proposed method was applied successfully for the analysis of the cited drugs in pure and dosage forms. Results of the proposed method were statistically compared with the reported methods by applying student's t- and F-tests and no significant differences were observed.
Author Related Publications
Rania Adel Sayed Ahmd, "The use of surface plasmon resonance band of green silver nanoparticles and conductometry for quantitative determination of minor concentrations of doxycycline hyclate and oxytetracycline HCl in pure and pharmaceutical dosage forms", Inderscience Publishers Ltd., 2020
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Rania Adel Sayed Ahmd, "Earth-friendly-assessed UV-spectrophotometric approaches for concurrent determination of mirabegron and solifenacin succinate in different matrices", Elsevier, 2023
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Rania Adel Sayed Ahmd, "Novel in Situ Electrochemical Strategy for Gatifloxacin Microdetermination in Urine Using Solid Contact and Disposal Screen-Printed Electrodes: a Comparative Study", springer, 2021
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Rania Adel Sayed Ahmd, "Different approaches for the assessment of greenness of spectrophotometric methodologies utilized for resolving the spectral overlap of newly approved binary hypoglycemic pharmaceutical mixture", elsevier, 2022
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Rania Adel Sayed Ahmd, "Green Stability Indicating Organic Solvent-Free HPLC Determination of Remdesivir in Substances and Pharmaceutical Dosage Forms", MDPI, 2021
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Department Related Publications
Abdallah Abdelaziem Abdallah Shlabi , "Micro and Semimicro Determination of Fluoride using ion-Selective Electrode and its Application in Phamaceutical Preparations", لايوجد, 1900
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Mervat Mohamed Hosny Ali Abdelmoniem, "Spectrophotometric estimation of some pharmaceutical compounds by charge transfere complexation", لايوجد, 1900
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Mervat Mohamed Hosny Ali Abdelmoniem, "Spectrophotometric methods for determination of enalapril and timolol in bulk and in drug formulations", لايوجد, 1900
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Rania Adel Sayed Ahmd, "Use Of Silver – Gelatin Complex For the Determination of Cefoperazone Sodium, Ceftazidime Pentahydrate and Cefotaxime Sodium in Pure and Pharmaceutical Dosage Forms", Chemical Science Review and Letters, 2012
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Wafaa Wafaa Alsayed Hassan Abdelatef Abolabn, "Use Of Silver – Gelatin Complex For the Determination of Cefoperazone Sodium, Ceftazidime Pentahydrate and Cefotaxime Sodium in Pure and Pharmaceutical Dosage Forms", Chemical Science Review and Letters, 2012
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