Background and Aim: Endometriosis is one of the most common gynecological diseases, affecting approximately 6–10% of all women. This study aimed to evaluate the effect of educational nursing strategies based on health promotion model on health patterns of women with endometriosis. Subjects & Methods: A quasi-experimental study was conducted at endoscopic unit and gynecological outpatient clinic at Zagazig University hospital via a purposive sample of 61 women with a medically confirmed laparoscopic diagnosis of endometriosis using the following tools; Structured interviewing questionnaire, health promotion lifestyle profile-II. Results: The findings revealed a statistically significant difference between both the level and the mean scores of women's information about endometriosis before and after nursing strategies based on a health promotion model (t-test =63.964& P<0.000) (t-test = 25.730& P <0.000) respectively. Additionally total mean scores of health-promoting model constructs increased from 114.16±14.89 before implementation to 173.79±7.73 after implementation of nursing strategies. Also, there was no statistically significant relation between women’s characteristics and level of women's information about endometriosis before and after nursing strategies implementation. Conclusion: Application of nursing strategies based on health promotion model improved women’s knowledge and had a positive effect on health patterns of women with endometriosis. Therefore, the study hypothesis was supported. Recommendations: Use booklets and posters as methods to increase women’s awareness regarding endometriosis to encourage them to adapt healthy life style.