‎ PURPOSE: ‎ To evaluate the safety and efficacy of retropupillary fixation of an iris-claw intraocular lens (IOL; Verisyse PMMA ‎IOL, Abbott Medical Optics [AMO], Netherlands) for the surgical correction of aphakia in microspherophakic eyes ‎without sufficient capsular support. ‎ DESIGN: ‎ Prospective interventional non-comparative case series. ‎ METHODS: ‎ This interventional case series comprised 17 eyes of 9 microspherophakic patients. Retropupillary fixation of the ‎Verisyse iris-claw IOL [AMO] was performed in all cases. The surgical time was measured. Corrected distance ‎visual acuity (CDVA), astigmatism, intraocular pressure, tissue reaction, pigment dispersion and stability of the IOL ‎were studied 1 day, 3 days, 1 week, 2 weeks, 1 month and 6 months postoperatively. ‎ RESULTS: ‎ Eight patients had familial microspherophakia and one patient had Marfan's syndrome. Eighty-two percent of the ‎cases achieved a visual acuity of 0.3 or better. There was no significant postoperative inflammatory reaction. ‎Transient elevation of IOP was recorded in two cases in the first week only. One IOL developed disengagement of ‎one of the haptics from the iris and was successfully re-engaged. All the other IOLs were well centred and stable. ‎The mean surgical time was 18.0 ± 4.5 min. ‎ CONCLUSIONS: ‎ Retropupillary fixation of an iris-claw IOL is a safe and effective procedure that provides early visual recovery. It is ‎also a time-saving method for correcting aphakia in microspherophakic eyes without sufficient capsular support. ‎