Background: Type 2 diabetes mellitus (T2D) is a global heath burden that is recently viewed as a state of chronic low-grade inflammation involving activation of immunological and inflammatory responses. Tumor necrosis factor‐ alpha (TNF‐ α) is a well-known pro inflammatory cytokine produced mainly by adipose tissues that plays a predominant role in development of insulin resistance in obese population. Thus, several researchers have hypothesized that circulating TNF‐ α levels in diabetic patients can influence diabetic control Objectives: The aim of the study was to analyse the relationship between the proinflammatory cytokine TNFα, C-reactive protein (CRP), ESR and HbA1c in patients with type2 diabetes mellitus to evaluate the impact of these inflammatory markers on glycemic control. Subjects and methods: This study included eighty-four Type 2 DM patients from patients admitted to internal medicine department in Zagazig University Hospitals. Routine laboratory investigations, TNF -α, ESR, CRP and HbA1c were collected and analyzed in all studied population. Results: We found significant association between serum TNF-α and serum HbA1c. These results supports the impact of TNF-α on glycemic control in T2D patients. Conclusion: Serum TNF-α and CRP levels are elevated in type-2 diabetic patients and their levels correlate with level of HBA1c. This supports the impact of inflammation on glycemic control.