Background: Aberrant phenotype is a phenomenon in which lymphoid-associated and other myeloid lineage markers expressed in myeloblasts or myeloid-associated markers expressed in lymphoblasts. Occurrence of aberrant phenotype that has been reported in acute leukemias with varying frequency though its prognostic importance still remains controversial. So the aim of this prospective cohort study was evaluation the outcome of de novo AML patients expressing lymphoid markers(Ly+ AML) correlated with cytogenetic pattern and clinicobiological features. Metods: our prospective cohort study designed to evaluate de novo adult patients having primary AML with the exclusion of acute promyelocytic leukemia admitted to the clinical Hematology Unit, Internal Medicine Department, in a tertiary referral hospital in Egypt, from July 2016 to the June 2019.ResultsPatients were classified according their lymphoid …