Background: Hypertensive disorders of pregnancy (PIH) are an important cause of severe morbidity, long-term disability, and death among both mothers and their babies. Aim: The aim of the study was to evaluate the safety bundle application on nurses’ knowledge and performance regarding management of hypertension during pregnancy and postpartum period. Patients and methods: A quasi-experimental design (pretest and posttest) was used. A purposive sample of all nurses (50 nurses) working in the obstetric hospital at Zagazig University hospitals was used in the period from January 2021 till May 2021. Two tools were used in this study: structured interviewing questionnaire that included sociodemographic data and data regarding nurses’ knowledge about management of hypertension during pregnancy and postpartum period and observational checklist to evaluate nurses’ performance about management of hypertension during pregnancy and postpartum period. Results: There were highly statistical significant differences preintervention and postintervention regarding nurses’ knowledge and performance about management of hypertension during pregnancy and postpartum period. Conclusion: The application of safety bundle program has a positive effect on nurses’ knowledge and practice regarding management of hypertension during pregnancy and postpartum period with a highly statistically significant difference. Recommendation: Continuous educational program to improve nurses’ knowledge and performance regarding application of safety bundle in management of hypertension during pregnancy and postpartum period. Keywords: hypertension, postpartum period, pregnancy, safety bundle.