Background: Endometriosis is among the most common gynecological diseases, which could have considerable physical, psychological, and social effects on the patient's Life. Endometriosis affects the safety and wellness of women, and decreases the physical quality of life. Aim of the study was to improve quality of life among women with endometriosis .Subjects& methods: Research design: A quasi-experimental design was used. Setting: the study was carried out in obstetrics and gynecology outpatient clinic at Zagazig university hospitals, Sharkia Governorate, Egypt, between the period from July 2017to January 2018. Subjects: a purposive sample of 60 women diagnosed with endometriosis and divided equally into intervention and control groups. Tools of data collection: Four tools were used in this study. A structured interviewing questionnaire, Numerical rating scale, Endometriosis Health Profile Questionnaire-30 and intervention program. Results: The findings of this research showed that, there was no statistically significant difference in demographic and obstetric characteristics between two groups (p 0.05). There are significant improvement regarding quality of life and decreasing level of pain among the intervention group than the control group after using of self-management strategies than pre assessment. Conclusion: The educational program about self-management strategies to cope with endometriosis has a significant improvement of women's quality of life. Recommendations: Provide continuous health educational program on self-management strategies for women diagnosed with endometriosis to improve quality of life and reduce pain. Keywords: endometriosis, quality of life, intervention study.