Background: The Spread of the COVID-19 disease has intensely affected the psychosomatic and physical wellbeing of the general population, including patients with chronic illness. Aim of study: This study aimed to evaluate the effect of intervention study on psychosomatic disorders and therapeutic compliance regarding COVID-19 susceptible patients. Research Design: A quasi-experimental design was used in carrying out this study. Study sample: A purposeful sample of 30 COVID- 19 susceptible patients in pre-test, as well as the same sample in post-test was recruited for the study. Study Setting: The study was conducted at outpatients’ clinics of chronic diseases in Zagazig University Hospitals, Egypt. Tools of data collection: Seven tools were used in this study; A structured Interviewing Questionnaire for patients, Observational Checklists, Beck Anxiety Inventory Scale, Zung Self-Rating Depression Scale, Perceived Stress Scale, Athens Insomnia Scale, and Therapeutic Compliance Scale. The study lasted six months started from the beginning of April 2020 to the end of September 2020. Results: Statistically significant improvements were detected in patients’ knowledge, practice, and therapeutic compliance post- intervention. There were statistically significant decreases of psychosomatic disorders as anxiety, depression, stress and insomnia for COVID-19 susceptible patients post- intervention. Conclusions: Intervention study was effective in improving patients' knowledge which consequently reflected on improving their practices and therapeutic compliance. Also, these changes were effective in relieving psychosomatic disorders for COVID-19 susceptible patients. Recommendation: It is recommended that the developed illustrated booklet to be available for those patients in all health care settings. Keywords: COVID-19, Psychosomatic Disorders, Therapeutic Compliance & Intervention Study