Background: Self-efficacy is an individual’s confidence in one’s ability to manage a chronic condition or change a health habit. Aim of the study: The aim of the study was to evaluate the effect of health education program on self efficacy and therapeutic compliance among patients with myocardial infarction in CCU at Zagazig University Hospitals. Subjects and Methods: Research design: A pre/post test quasi experimental design was used to achieve the aim of the study. Study Setting: The study was conducted in cardiac care unit at Zagazig University Hospitals, Subjects: Purposive sample of 35 adult patients. Tools of data collection: Three tools were used: An interview questionnaire for patients, Chronic disease Self- Efficacy Scale, and Compliance assessment scale. Implementation of the educational program lasted over a period of 8 months, starting from September 2018 to April 2019. Results: there was significant increase in patient' self efficacy of regular exercise, getting information about disease, obtaining support, communication with physician, management of disease, routine home activities, recreational and social activities, and manage depression post program than before with Mean ± SD 23.64±5.41, 7.69±1.79, 15.93±3.68, 25.89±5.88, 92.27±19.77, 23.73±5.79, 16.06±3.89, 51.53±8.91. Also, there was statistical significant improve in patient's compliance regarding dietary regimen, treatment regimen, and lifestyle modifications post program than before with mean ±SD 8.06±2.30, 9.69±1.97, 10.48±2.58. Conclusion: On the light of the current study results, it can be concluded that, there was a statistical significant increase in patient's self efficacy and improvement of therapeutic compliance regimen after implementing the effective health educational program. Recommendation: A simple written guidelines for patients with myocardial infarction should be available in units that provide care, to be provided to newly admitted patients, Self-efficacy for patients with myocardial infarction should be considered and evaluated during the plan for treatment of patient with MI by trained nurse. Key words: Myocardial Infarction (MI), Self efficacy, Therapeutic Compliance.