Background: Patients with chronic illnesses may experience extreme symptoms, including physical, spiritual, and psychosocial effects. Preventing and managing these symptoms while optimizing the quality of life throughout the dying process is the goal of palliative care. Aim of the study: The aim of the study was to evaluate the effect of palliative care program on nurses’ performance regarding prostate cancer and patient’s outcomes. Research design: A pretest/posttest quasi-experimental design was used to achieve the aim of the study. Study Setting: The study was conducted in the Oncology and Urology Departments at Zagazig University Hospital, Sharkia, Egypt. Study sample: A purposive sample of 30 nurses and 30 patients had been selected. Tools of data collection: Four tools were used: 1- A structured interviewing questionnaire for nurses, 2- Observational checklists for palliative care, 3-A structured interview questionnaire for patients, and 4- symptom index. Implementation of the palliative care program lasted over a period of 10 months, starting from March 2019 to December 2019. Results: The results of the present study showed that 83% of studied nurses had satisfactory level of knowledge post program. Moreover, 83.3% of studied nurses had satisfactory level of practice after the program implementation. There was improvement in patients’ compliance regarding nutrition, medication, and lifestyle after applying the palliative care program, with mean±SD of 9.1±1.71, 12.1±2.5, and 10.3±3.4, respectively. Moreover, 80% of the studied patients had decreased symptoms after the program, though the decrement was not significant. Conclusion: In light of the current study results, it can be concluded that the palliative care program had a positive effect on improving nurses’ knowledge and practice, which reflected then on improving patients’ outcomes. Recommendation: In-service training for newly recruited nurses will help to update their knowledge and improve their practice. Keywords: Nurses’ performance, Palliative care, Prostate cancer