Background: Cognitive skills play an important role in types of cognitive tasks, including verbal exchange of information, better comprehension of reading, motivation, verbal comprehension, writing, attention, problem solving, and social cognition. Aim of this study: To examine the effectiveness of metacognitive skills educational program on metacognitive awareness, self-efficacy, and problem solving skills among nursing students at the Faculty of Nursing Zagazig University. Subjects: A simple random sample (n= 70) of nursing students enrolled in fourth academic year 2019-2020. Tools of data collection: A questionnaire sheet was used for data collection including four parts: 1) Personal characteristics of the nursing students, 2) Metacognitive Awareness of Reading Strategies Inventory (MARSI), 3) General Self-efficacy Scale, and 4) The problem solving skills inventory. Results: revealed that there were statistically significant strong correlation between students' metacognitive awareness, self-efficacy, and problem solving skills after the educational program. Conclusion: Metacognitive skills educational program had positive influence in improving students' metacognitive awareness, self-efficacy, and problem solving skills. Recommendations: Encourage nurse educators to improve students' self-efficacy and problem solving abilities by putting specific approaches to improve thinking and embedding them in the various courses. Infuse educational courses dealing with metacognitive thinking skills, with paying attention to the growth of metacognitive thinking skills in all academic years.