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Clinicopathological evaluation of intralesional methotrexate in different subtypes of basal cell carcinoma
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Nelly Mohammed Saeed Abdul Rahman Muhammed
Journal:
Dermatologic Therapy Wiley
Volume:
Keywords :
Clinicopathological evaluation , intralesional methotrexate in different subtypes
Abstract:
Basal cell carcinoma (BCC) is the most common malignant skin tumor. While slowly growing, it can cause major skin disfigurement. Therefore, novel cosmetically acceptable treatment options, other than surgery require investigation. The aim of the study was to evaluate efficacy and safety of intralesional methotrexate (MTX) as a convenient modality for BCC treatment clinically and pathologically. A total of 20 patients with BCC of any clinical variant underwent intralesional MTX injection at a maximum 1 mL of 25 mg/mL MTX per session. Histopathological assessments were performed before and 1 month after treatment. Forty percent of patients showed >50% clinical improvement after 1–4 sessions. Intralesional MTX is a suitable and safe treatment modality for BCC and may be used as an adjuvant to surgery.
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Nelly Mohammed Saeed Abdul Rahman Muhammed, "Interleukin 23 and Interleukin 17 Evaluation Before and After Methotrexate Treatment of Basal Cell Carcinoma", Zagazig University, Faculty of Medicine, 2022
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Nelly Mohammed Saeed Abdul Rahman Muhammed, "Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study", springer, 2019
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Amal Mohamed Mahmoud Mangoud, "- DNA Ploidy and S-Phase Fraction in Certain Breast Lesions: A Comparative and Analysi 1 /11/1997 المجلة المجلة", لايوجد, 1900
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