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Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Asmaa Hussein Mohamed AbdelMaksoud
Journal:
Middle east journal of cancer Middle east journal of cancer
Volume:
Keywords :
Prognostic Performance , High Expression , KIF23 , Loss
Abstract:
Background: Kinesin family member 23 (KIF23) has an important role in mitosis of cytoplasmic separation process. Casitas B-lineage lymphoma (c-Cbl) is a protein ligase E3 ubiquitin in tyrosine kinase pathways, involved in numerous cell types. The current study aimed to evaluate the tissue expression of KIF23 and c-Cbl in gastric cancer (GC) tissues and normal gastric mucosa using immunohistochemistry and to investigate the correlation among their expressions, clinicopathological parameters, and the prognosis of patients in order to detect their role in the progression of GC and patients’ prognosis. Method: We conducted this prospective study on 120 samples retrieved from 120 patients; 80 samples were taken from GC patients and 40 from normal gastric mucosa. We assed tissue protein expression of KIF23 and c-Cbl using immunohistochemistry. We evaluated the correlations between KIF23 and C-Cbl expression with clinicopathological and prognostic parameters of patients. Results: KIF23 expression level in GC tissues was positively correlated with high pTNM stage (P = 0.001), larger tumor size (P = 0.010), high tumor grade (P = 0.006), poor overall survival (P < 0.001), disease-free survival rates (P = 0.003), and tumor recurrence after therapy (P = 0.004). c-Cbl expression level in GC tissues was positively correlated with early pTNM stage (P = 0.003), lower tumor grade (P = 0.005), the absence of lymph node metastasis (P = 0.023), good response to therapy (P = 0.002), and the absence of tumor recurrence after the therapy (P = 0.004). Conclusion: The high KIF23 expression and low c-Cbl expression in GC tissues were attributed to progression and poor prognosis in gastric cancer patients.
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Department Related Publications
Amal Mohamed Mahmoud Mangoud, ": The 1st International Conference of Oncology Diagnostic Unit (the main theme: Recent Scientific Technology). 1 /4 /1997 المجلة المجلة", لايوجد, 1900
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Amal Mohamed Mahmoud Mangoud, "About 100 research papers in Tumors and Different Diseases and publication of some of them at the American Internet 1 /4 /2004 المجلة المجلة", لايوجد, 1900
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Amal Mohamed Mahmoud Mangoud, "Clinical and Pathological Study for Evaluation of Head and Neck Tumors in ENT 1 /11/1998 المجلة المجلة", لايوجد, 1900
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Amal Mohamed Mahmoud Mangoud, "- Androgen Receptor Expression and its Relation to PCNA and Ki-67 in Prostat Cancer 1 /10/2005 المجلة المجلة", لايوجد, 1900
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Amal Mohamed Mahmoud Mangoud, "Angiogenesis and Cell Proliferation as Prognostic Indices in Glial Tumors 1 /11/2004 المجلة المجلة", لايوجد, 1900
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