The goal of the study is to create a rehabilitation program for patients with breast cancer outside and inside the aqueous medium of the upper extremity after surgery and during chemotherapy, as well as to determine its impact on various variables (physical, physiological and psychological). For the two groups, the researcher used the experimental method with an experimental design, one of which was experimental (physical, physiological, and mental). The research population consisted of )38( female patients who had mastectomy and were at the chemotherapy stage, as well as the frequency of the oncology department at the University Hospital of Oncology in Zagazig for whom the conditions applied. The research sample was chosen, and those who wanted to participate in the research experiment were chosen, and their number reached (32) patients. So ten (10) patients were withdrawn in order to conduct the exploratory study on them, and thus the basic sample became (22) patients divided into two equal groups of strength, each of whom consisted of eleven (11) women. The rehabilitation program for the upper extremity of the body was implemented for a period of twelve weeks, with three units per week, and the program units included three parts (physical preparation, the main part, and the final part). The rehabilitation program had a positive effect on physical variables (shoulder joint flexibility, arm grip strength on the side of the operation, forearm circumference, humerus circumference), as well as physiological and psychological variables (heart rate, systolic and diastolic blood pressure, vital capacity, maximum oxygen consumption) as well as an improvement in psychological aspects (general mood, quality of life, depression). The results also indicated that the experimental group outperformed the control group in all of the variables studied.