Journal: |
gulf journal of oncology
gulf journal of oncology
|
Volume: |
|
Abstract: |
Background: Tumor-infiltrating lymphocytes (TILs)
reflect the antitumor response of the host. This study
aimed to assess the value of TILs in predicting pathological
response after neoadjuvant chemotherapy (NAC) and
survival outcomes in patients with triple-negative breast
cancer (TNBC).
Methods: A retrospective analysis conducted between
February 2012 and December 2015. Patients with stage I,
II, and III TNBC patients were enrolled. TILs were assessed
in haematoxylin and eosin-stained sections from true cut
needle biopsies before NAC. According to international
TILs working group, we had three groups; low (0-10%),
intermediate (11-59%), and high TILs (≥ 60%).
Results: A total of 159 patients was included, 56% were
premenopausal and 76.1% were less than 60 years. The
main bulk of patients had histological grade III, high Ki 67,
and high TILs (74.2%, 84.3%, and 72.3%), respectively.
Original Article
Predictive and Prognostic Value of Tumor- Infiltrating
Lymphocytes for Pathological Response to Neoadjuvant
Chemotherapy in Triple Negative Breast Cancer
Amrallah A. Mohammed1,2, Fifi Mostafa Elsayed3 Mohammed Algazar4, Hayam E Rashed5
1 Medical Oncology Department, Faculty of Medicine, Zagazig University, Egypt.
2Oncology Center, King Salman Armed Forces Hospital, Tabuk City, Saudi Arabia.
3Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.
4Department of General Surgery, Faculty of Medicine, Zagazig University, Egypt.
5Department of Pathology, Faculty of Medicine, Zagazig University, Egypt.
Corresponding Author: Dr. Amrallah A. Mohammed
MBBCh, MSc, MD., 29 Saad Zaghloul,
Postal code, 44519, Egypt.
E-mail: amrallaabdelmoneem@yahoo.com.
T; 00201224141040. Fax; +966125532239.
The pre-treatment high TILs was significantly correlated
with high Ki-67 (p = 0.001), pCR (p <0.001), and late
relapse (p <0.001). Other clinico-pathological features
such as age, menopausal status, tumor size, histological
grade, lymph node involvement and lympho-vascular
invasion weren’t significantly correlated with TILs levels.
71.3% of enrolled patients having high TILs achieved
pCR, vs 27.8% in the intermediate group and 30.8% in
low group. After a median follow-up of 45.3 months,
patients with high TILs were significantly associated with
longer DFS and OS as compared to intermediate and low
TILs (27.2 vs 15.9 vs11.4 months for DFS and 70.2 vs
34.3 vs 27.6 months for OS) p<0.001).
Conclusions: Pre-treatment level of TILs had a predictive
and prognostic value in TNBC patients receiving NAC.
TILs may be integrated into the basic laboratory for TNBC
prognostication as a credible biomarker.
|
|
|