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Gulf J Oncolog
Gulf J Oncolog
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Abstract: |
Objective: The study proposed to assess the relation
between the body mass index (BMI) and clinicopathological
features of metastatic urinary bladder cancer
(uBCa) and the influence on survival outcome.
Method: A retrospective study included 201 metastatic
uBCa patients. They classified into three groups according
to BMI, group I; a BMI of 18.5 – 24.9 kg/m2, group II; a
BMI of 25-29.9 kg/m2, and group III; BMI ≥ 30 kg/m2.
The Kaplan – Meier curve used for survival analysis.
Results: 69 patients (34.3%) belonged to group I, 75
patients (37.3%) belonged to group II, and 57 patients
(28.4%) belonged to group III. Smoking history was
detected in 44.8% of patients with Performance Status
(PS) 0 in 55.2%, and PS 1 in 26.9%. Of note, 44.8% of
patients responded to 1st chemotherapy and 50.7%
The effect of body mass index on clinico-pathological
features and survival outcome in metastatic bladder
carcinoma
Amrallah A. Mohammed 1, Ayman elshentenawy2, Fifi Mostafa Elsayed3
1 Medical Oncology Department, Faculty of Medicine, Zagazig University, Egypt.
1King Salman Armed Forces Hospital-Tabuk City, KSA.
2Kasr EL Einy center of clinical oncology and nuclear (NEMROCK), Cairo university, Egypt.
3Clinical Oncology & Nuclear medicine Department faculty of medicine Suez Canal University, Egypt.
Corresponding Author: Dr; Amrallah A. Mohammed
MBBCh, MSc, MD., Prof. of Medical Oncology,
Faculty of medicine, Zagazig University, Egypt /
Consultant of medical oncology in
King Salman Armed Forces Hospital-Tabuk City, KSA.,
29 Saad Zaghloul, Postal code, 44519, Egypt ,
E-mail: amrallaabdelmoneem@yahoo.com,
T; 00201224141040
received more than 2 lines. Through the univariate
analysis, poor prognostic outcome was associated with
male (P= 0.01), smoking (P=0.002), BMI group II and
group III (p=0.00), PS 2 compared with PS 0 (P<0.001),
metastasis to liver, lung, and lymph node (P<0.001),
and no response to first line chemotherapy (P<0.001).
While no effect for age (P=0.1), bone metastasis (P=0.6),
serum LDH (P=0.1), serum albumin (P=0.4), and ≥2
chemotherapy lines (P=0.5) on survival outcome. After
the follows-up period, the OS was 12.7 months for all
patients. Regarding the BMI groups, the median OS was
23.5 months, 12.9 months, and 10.2 months for group I,
group II, and group III respectively (p=<0.001).
Conclusion: High BMI associated with aggressive
clinico-pathological features and poor survival outcome
in metastatic uBCa.
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