Background: Increasing attention is being paid to the role of inflammatory markers and their relationship to the severity of coronary artery disease. Our aim was to prove that simple complete blood count (CBC) indices , platelet / lymphocyte ratio (PLR) , neutrophil / lymphocyte ratio (NLR) and mean platelet volume (MPV) can assess severity of coronary artery calcium using multi detector CT (MDCT). Methods: 70 male patients who were scheduled for CT coronary angiography (CTCA) for chest pain or multiple risk factors for coronary artery disease (CAD) were prospectively enrolled. Blood samples for complete blood count, differential leucocyte count and full lipid profile were collected. Results: There was a significant negative correlation between NLR ratio and coronary artery calcium score (CACs) (P-value <0.05) and between neutrophil count and number of involved vessels (P-value <0.05). A significant positive correlation was found between MPV, segment involvement score (SIS) and segment stenosis score (SSS) and number of involved vessels (P-value=0.05, 0.01 and 0.01) respectively. Logistic regression analysis showed that PLR and NLR are independent predictors of a calcific plaque (P=0.023 and 0.028) respectively. Conclusion: NLR & PLR proved to be good predictors of calcific plaque. Key words: Mean platelet volume; Platelet/lymphocyte Ratio; Neutrophil/lymphocyte ratio; Coronary artery disease; Multi detector computed tomography angiography.