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In Silico Designing of a Multitope Vaccine against Rhizopus microsporus with Potential Activity against Other Mucormycosis Causing Fungi
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
25
Authors:
Ashraf Alsayed Sleim
Staff Zu Site
Abstract In Staff Site
Journal:
cells cells
Volume:
Keywords :
, Silico Designing , , Multitope Vaccine against Rhizopus microsporus
Abstract:
During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been reported globally, with elevated rates of infection in India, and because of the high rate of mortality and morbidity, designing an effective vaccine against mucormycosis is a major health priority, especially for immunocompromised patients. In the current study, we studied shared Mucorales proteins, which have been reported as virulence factors, and after analysis of several virulent proteins for their antigenicity and subcellular localization, we selected spore coat (CotH) and serine protease (SP) proteins as the targets of epitope mapping. The current study proposes a vaccine constructed based on top-ranking cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and B cell lymphocyte (BCL) epitopes from filtered proteins. In addition to the selected epitopes, -defensins adjuvant and PADRE peptide were included in the constructed vaccine to improve the stimulated immune response. Computational tools were used to estimate the physicochemical and immunological features of the proposed vaccine and validate its binding with TLR-2, where the output data of these assessments potentiate the probability of the constructed vaccine to stimulate a specific immune response against mucormycosis. Here, we demonstrate the approach of potential vaccine construction and assessment through computational tools, and to the best of our knowledge, this is the first study of a proposed vaccine against mucormycosis based on the immunoinformatics approach.
Author Related Publications
Ashraf Alsayed Sleim, "miRNA-223-3p, miRNA- 2909 and Cytokines Expression in COVID-19 Patients Treated with Ivermectin", Zagazig University Medical Journal, 2022
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Ashraf Alsayed Sleim, "Comparing the Asthma Control and Anti-inflammatory Effects of Different Fixed Combinations of Inhaled Corticosteroids Plus Long-acting Beta 2 Agonist; A Randomized Clinical Trial", Open Access Macedonian Journal of Medical Sciences, 2021
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Ashraf Alsayed Sleim, "Effect of bronchial asthma education program on asthma control among adults at Mansoura district", Egyptian Journal of Chest Diseases and Tuberculosis, 2017
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Ashraf Alsayed Sleim, "Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients", egyptian journal of chest diseases and tuberculosis, 2014
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Ashraf Alsayed Sleim, "Serum uric acid as a biomarker for prediction of outcomes of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease", Egyptian Journal of Bronchology, 2014
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Department Related Publications
Hanan Mohamed Elsehaat, "قيمة أيزوإنزيمات اللكتات ديهيدروجينيز فى تشخىص الإنسكاب البلورى", لايوجد, 1900
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Hanan Mohamed Elsehaat, "دراسة بعض عوامل الخطورة للربو الشعبي ذو العامل الوراثي في مرحلة الطفولة", لايوجد, 1900
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Hanan Mohamed Elsehaat, "نظام تقييم التدخل العلاجى المبسط-28 فى وحدة الرعاية المركزة التنفسية بالزقازيق", لايوجد, 1900
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Hanan Mohamed Elsehaat, "مقارنة للطرق المختلفة لفطام مرضي السدة الرئوية المزمنة الخاضعين للتهوية الميكانيكية", لايوجد, 1900
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Ramadan Mahmoud Elsayed Nafea, "chest mass miniature radiography (MMR) results among symptomatic and asymptomatic subjects ", لايوجد, 1900
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