Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Toll-Like Receptor-4 Gene (Asp299Gly) polymorphism in allergic conjunctivitis
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Shereen Atef Sayed Baioumy
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Immunology Elsevier
Volume:
Keywords :
Toll-Like Receptor-4 Gene (Asp299Gly) polymorphism , allergic
Abstract:
Allergic conjunctivitis (AC) is an allergic reaction that causes inflammation of the conjunctiva. Toll-like receptors (TLRs) are essential innate immune receptors that contribute to developing various allergic diseases. This case-control study aims to determine the correlation between TLR-4 gene (Asp299Gly) polymorphism and AC incidence and severity. The study included 70 AC patients and 70 non-allergic controls. All included subjects were subjected to a skin prick test, total immunoglobulin E (IgE) measurement, and TLR-4 gene (Asp299Gly) polymorphism detection by PCR restriction fragment length polymorphism (PCR-RFLP) technique. AC patients had significantly higher total IgE levels than controls (P ≤ 0.001). The frequency of the wild-type AA and heterozygous AG genotype were significantly lower in AC patients compared to controls (60 % vs. 80 % and 8.6% vs. 12.9 %, respectively). In contrast, the homozygous mutant GG genotype was significantly more prevalent among AC patients than controls (31.4 % vs. 7.1 %). Furthermore, the wild AA genotype was strongly associated with mild disease (68.2%); nonetheless, the homozygous mutant GG genotype was linked to severe disease (53.8%). The heterozygous AG genotype was only found in moderate AC patients (17.1%). AC patients with the mutant G allele may be more likely to have a severe course of AC.
Author Related Publications
Shereen Atef Sayed Baioumy, "A Study on T Regulatory Cells in Patients with Respiratory Allergies in Zagazig University Allergy and Immunology Unit", egyptian journal of medical microbiology, 2016
More
Shereen Atef Sayed Baioumy, "Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables.", Elsevier, 2018
More
Shereen Atef Sayed Baioumy, "Diagnostic and prognostic roles of peripheral blood Toll-like receptor-4 and stanniocalcin-1 genes expression in acute lung injury", Elsevier, 2019
More
Shereen Atef Sayed Baioumy, "Role of circulating microRNA-132 in allergic bronchopulmonary aspergillosis: A case-control study", Elsevier, 2021
More
Shereen Atef Sayed Baioumy, "Association between serum zonulin level and severity of house dust mite allergic asthma", BMC, 2021
More
Department Related Publications
Ashwak Mohamed Foad Abotaleb, "استخدام سلسله تفاعل البلمره المتسلسل مع زوج واحد من البادئات لتشخيص تفطر الدم المسبب بثلاثة انواع من الفطور في الاطفال حديثى الولادة", لايوجد, 1900
More
Ayman Abdelrahman Hussinn, "الخصائص السريرية و الميكروبية لعدوى المستشفيات التى تسببها انواع البكتيريا الراكدة", لايوجد, 1900
More
Hanan Mohamed Elsayed Ibrahiem, "Diagnosis of Acute Bacterial Endophthalmitis By Nested Polymerase Chain Reaction", لايوجد, 1900
More
Hanan Mohamed Elsayed Ibrahiem, "Chlamydia trachomatis detection by polymerase chain reaction (PCR) in infertile women using a tubal cytobruch during laparoscopy. 1 /11/1999 Zagazig University Medical J ", لايوجد, 1900
More
Alaaeldeen Abdelbaset Hadhoud, "Plasmid profile analysis of tmp resistance negative bacilli among patients unit", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف