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Role of circulating microRNA-132 in allergic bronchopulmonary aspergillosis: A case-control study
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Shereen Atef Sayed Baioumy
Staff Zu Site
Abstract In Staff Site
Journal:
Immunobiology Elsevier
Volume:
Keywords :
Role , circulating microRNA-132 , allergic bronchopulmonary aspergillosis:
Abstract:
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic respiratory disease. In the current study, we aimed to evaluate the roles of miRNA-21 and miRNA132 as biomarkers in the diagnosis of ABPA. A total of 30 controls, 30 allergic asthmatic patients, 30 severe asthma with fungal sensitization (SAFS) patients, and 30 ABPA patients were included. Real-time polymerase chain reaction was used to quantify the level of miRNAs expression. The expression level of miRNA-21 was significantly higher in allergic asthmatic, SAFS, and ABPA patients in comparison with controls (p < 0.001). However, no significant difference was detected in the expression level of miRNA-21 among the different patient groups (p > 0.05). The ABPA patients had significantly higher levels of miRNA-132 expression compared to controls, allergic asthmatic patients, and SAFS patients (p < 0.001), but there was a non-significant difference between controls and allergic asthmatic patients (p = 0.09). At a cut-off of 1.52, the sensitivity of miRNA-132 expression was 93.3% and the specificity was 100% different ABPA from healthy controls. At a cut-off of 6.5, miRNA-132 expression was found to reliably differentiate between ABPA and SAFS, with a sensitivity of 86.7% and a specificity of 80%. In ABPA patients, miRNA-132 expression positively correlation with the levels of serum IL-5 (r = 0.91, p < 0.001). miRNA-132 has a role in ABPA detection and distinguishing ABPA from allergic asthma and SAFS. These preliminary data from case-control study need further studies to confirm its finding.
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Shereen Atef Sayed Baioumy, "A Study on T Regulatory Cells in Patients with Respiratory Allergies in Zagazig University Allergy and Immunology Unit", egyptian journal of medical microbiology, 2016
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Shereen Atef Sayed Baioumy, "Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables.", Elsevier, 2018
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Shereen Atef Sayed Baioumy, "Diagnostic and prognostic roles of peripheral blood Toll-like receptor-4 and stanniocalcin-1 genes expression in acute lung injury", Elsevier, 2019
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Shereen Atef Sayed Baioumy, "Association between serum zonulin level and severity of house dust mite allergic asthma", BMC, 2021
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Shereen Atef Sayed Baioumy, "Interleukin-17A serum levels in young patients with atopic dermatitis and food allergy", Elsevier, 2021
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Department Related Publications
Amal Hassan Mahmoud Atta , "hlaclass-ii genotyping of egyptian childrenwith rheumatic heart disease in sharkea governorate ", لايوجد, 1900
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