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Diagnostic and prognostic roles of peripheral blood Toll-like receptor-4 and stanniocalcin-1 genes expression in acute lung injury
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Shereen Atef Sayed Baioumy
Staff Zu Site
Abstract In Staff Site
Journal:
Immunobiology Elsevier
Volume:
Keywords :
Diagnostic , prognostic roles , peripheral blood Toll-like
Abstract:
Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (20 healthy controls, 28 ALI patients) and expressions of genes were assessed by real-Time qRT-PCR. The expression levels of TLR-4 and SCT-1 genes were significantly lower in ALI patients compared to controls (P < 0.0001). After 10 days, the expression levels of TLR-4 and SCT-1 were increased compared to their baseline levels (p=0.012 and 0.024, respectively). SCT-1 has 92.9% sensitivity and 100% specificity in ALI detection. SCT-1 gene expression was negatively correlated with severity score (r= −0.54, p=0.003). The mortality pattern was higher in ALI patients with lower TLR-4 gene expression (p=0.014). In conclusion, the peripheral blood expressions of TLR-4 and STC-1 genes were decreased in ALI patients. Both genes expressions were increased with patients' recovery. SCT-1 had higher sensitivity and specificity in ALI diagnosis. The peripheral blood expressions of SCT-1 and TLR- 4 genes seem to be diagnostic and prognostic markers in ALI.
Author Related Publications
Shereen Atef Sayed Baioumy, "A Study on T Regulatory Cells in Patients with Respiratory Allergies in Zagazig University Allergy and Immunology Unit", egyptian journal of medical microbiology, 2016
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Shereen Atef Sayed Baioumy, "Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables.", Elsevier, 2018
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Shereen Atef Sayed Baioumy, "Role of circulating microRNA-132 in allergic bronchopulmonary aspergillosis: A case-control study", Elsevier, 2021
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Shereen Atef Sayed Baioumy, "Association between serum zonulin level and severity of house dust mite allergic asthma", BMC, 2021
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Shereen Atef Sayed Baioumy, "Interleukin-17A serum levels in young patients with atopic dermatitis and food allergy", Elsevier, 2021
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Department Related Publications
Amal Hassan Mahmoud Atta , "hlaclass-ii genotyping of egyptian childrenwith rheumatic heart disease in sharkea governorate ", لايوجد, 1900
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Hanan Mohamed Elsayed Ibrahiem, "Accuracy of amniotic fluid interleukin-6, glucose, white blood cell count and gram stain in detection of microbial invasion of the amniotic cavity in patients with preterm premature rupture of membranes.", لايوجد, 1900
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Alaaeldeen Abdelbaset Hadhoud, "The value of release chain reaction and rest gelectyim ezyam a malysis (PRA) completed with that commentinal and bio chemical tests ", لايوجد, 1900
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Awny Ali Aboelmoaz Ghawesh, "الالتهاب الكبدي المناعي (النوع الثانى)مقارنة بالالتهاب الكبدى الفيروسي(سى)", لايوجد, 1900
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Awny Ali Aboelmoaz Ghawesh, "العلاقه الوثيقة بين الانترلوكين 10 والالتهاب المفصلي الروماتيدي", لايوجد, 1900
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