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Serum Angiopoietin-2: A Sensitive Inflammatory Marker in Psoriasis Patients
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Hagar Awad Abdel Aziz Bisar
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Chemistry ekb
Volume:
Keywords :
Serum Angiopoietin-2: , Sensitive Inflammatory Marker , Psoriasis
Abstract:
Psoriasis is an immune-mediated inflammatory skin disease associated with comorbidities. Angiogenesis plays a pivotal role in psoriasis pathogenesis which contributes to the initial events that trigger an autoimmune inflammatory response. Angiopoietins 1 and 2 are glycoproteins. Their binding to the tyrosine kinase receptor is essential to angiogenesis. Dysregulation of angiopoietins together with angiopoietin-2 overexpression induce vascular destabilization and regression. This study aimed to explore the relationship between systemic angiopoietin-2 and psoriasis severity. A total of 45 psoriasis vulgaris patients and 45 matched healthy controls were enrolled in the study. The severity of disease was evaluated by Psoriasis Area and Severity Index. Angiopoietin-2 serum level was measured using enzyme linked-immunosorbent assay. The relation between serum level of angiopoietin-2 and psoriasis severity was assessed. Angiopoietin-2 serum level was significantly more elevated in patients than controls (p < 0.001). Angiopoietin-2 serum level was indicatively direct correlated with disease severity (r = 0.7, p < 0.001) with 100% sensitivity and 90.9% specificity in identifying mild and moderate to severe psoriasis patients. Serum angiopoietin-2 directly correlates with psoriasis severity. Angiopoietin-2 is nominated to be a potential sensitive biomarker for the ongoing inflammatory process to monitor the clinical and therapeutic outcomes in psoriasis patients.
Author Related Publications
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Hagar Awad Abdel Aziz Bisar, "Serum angiopoietin-2 level as a novel potential biomarker in oral lichen planus", wiley, 2021
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