Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFRwt and aromatase (CYP19A) inhibitors; a study supported by molecular docking†

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Journal: RSC Advances Royal Society of Chemistry Volume:
Keywords : Chemical constituents from Carica papaya Linn.    
Abstract:
Phytochemical investigation of the hydromethanolic extract of Carica papaya Linn. leaves (Caricaceae) resulted in the isolation and characterization of ten compounds, namely; carpaine (1), methyl gallate (2), loliolide (3), rutin (4), clitorin (5), kaempferol-3-O-neohesperidoside (6), isoquercetin (7), nicotiflorin (8) and isorhamnetin-3-O-β-D-glucopyranoside (9). Methyl gallate and nicotiflorin exhibited potential EGFRwt kinase inhibition activities. Clitorin and nicotiflorin displayed the strongest aromatase kinase inhibition activities
    
     
 
       

Author Related Publications

  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2−/− female mice with lipodystrophy", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility", Oxford University Press, 2015 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation", Oxford University Press, 2015 More

Department Related Publications

  • Hanan Hamdy Mahmoud Ibrahiem, "Study on the Molecular Mechanisms Involved Renal tissue injury", لايوجد, 1900 More
  • Rasha Hassan Abdelghani Hassan , "Effect of lansoprazole on gastric secretion, prostaglandin £2 and plasma", لايوجد, 1900 More
  • Nabila Noureldeen Mostafa Elmaraghy, "Pharmacological Studies on the possible Interactions between Some Analgesics", لايوجد, 1900 More
  • Mohammed Nagieb Mohamed Zakarya Hassan , "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 More
  • Hany Mohamed Abdelmalek Mahmoud ElBassossy, "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 More
Tweet