Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFRwt and aromatase (CYP19A) inhibitors; a study supported by molecular docking†

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Journal: RSC Advances Royal Society of Chemistry Volume:
Keywords : Chemical constituents from Carica papaya Linn.    
Abstract:
Phytochemical investigation of the hydromethanolic extract of Carica papaya Linn. leaves (Caricaceae) resulted in the isolation and characterization of ten compounds, namely; carpaine (1), methyl gallate (2), loliolide (3), rutin (4), clitorin (5), kaempferol-3-O-neohesperidoside (6), isoquercetin (7), nicotiflorin (8) and isorhamnetin-3-O-β-D-glucopyranoside (9). Methyl gallate and nicotiflorin exhibited potential EGFRwt kinase inhibition activities. Clitorin and nicotiflorin displayed the strongest aromatase kinase inhibition activities
    
     
 
       

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