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Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation
Faculty
Pharmacy
Year:
2017
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Staff Zu Site
Abstract In Staff Site
Journal:
Biology of reproduction Oxford University Press
Volume:
Keywords :
Seipin deficiency leads , increased endoplasmic reticulum
Abstract:
Significantly reduced percentage of larger lipid droplets was detected in LD1 Bscl2−/− alveoli. No obviously impaired proliferation detected by PCNA but increased apoptosis detected by cleaved caspase-3 in alveolar epithelial cells. Increased expression of protein disulfide isomerase and binding immunoglobulin protein indicated increased ER stress. This study demonstrates novel in vivo functions of seipin in ER stress and apoptosis
Author Related Publications
Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice", Elsevier, 2014
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Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice", Elsevier, 2014
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Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2−/− female mice with lipodystrophy", Elsevier, 2014
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Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility", Oxford University Press, 2015
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Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation", Oxford University Press, 2015
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Department Related Publications
Hassan Mahmoud Mohamed Elfayomy , "Pharmacological Studies on the Possible Interaction between some psychotropics& ", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "A comparative study of centrally and peripherally administered", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "The modulatory effect of antidiabetic drugs on thyroid function in diabetic", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "Does vitamin B]&6 modulate the hypolipidemic effect of complamin,", لايوجد, 1900
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Mohammed Nagieb Mohamed Zakarya Hassan , "Evidence that free radicals may contribute to the development of rinduced arrhythmias in the isolated rat heart", لايوجد, 1900
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