Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Journal: Biology of reproduction Oxford University Press Volume:
Keywords : Seipin deficiency leads , increased endoplasmic reticulum    
Abstract:
Significantly reduced percentage of larger lipid droplets was detected in LD1 Bscl2−/− alveoli. No obviously impaired proliferation detected by PCNA but increased apoptosis detected by cleaved caspase-3 in alveolar epithelial cells. Increased expression of protein disulfide isomerase and binding immunoglobulin protein indicated increased ER stress. This study demonstrates novel in vivo functions of seipin in ER stress and apoptosis
    
     
 
       

Author Related Publications

  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2−/− female mice with lipodystrophy", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility", Oxford University Press, 2015 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation", Oxford University Press, 2015 More

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