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Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats
Faculty
Not Specified
Year:
2012
Type of Publication:
Article
Pages:
774-779
Authors:
Elshazly, Shimaa M, Zaitone, Sawsan A, Abo-Elmatty, Dina M
DOI:
10.4103/0253-7613.103300
Journal:
INDIAN JOURNAL OF PHARMACOLOGY MEDKNOW PUBLICATIONS \& MEDIA PVT LTD
Volume:
44
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000311421200022
Keywords :
Dopamine, Parkinsons disease, piracetam, rotenone, vinpocetine
Abstract:
Objective: To evaluate the neuroprotective effect of the nootropic drugs, piracetam (PIR) and vinpocetine (VIN), in rotenone-induced Parkinsonism in rats. Materials and Methods: Sixty male rats were divided into 6 groups of 10 rats each. The groups were administered vehicle, control (rotenone, 1.5 mg/kg/48 h/6 doses, s.c.), PIR (100 and 200 mg/kg/day, p.o.) and VIN (3 and 6 mg/kg/day, p.o.). The motor performance of the rats was evaluated by the open field and pole test. Striatal dopamine level, malondialdehyde (MDA), reduced glutathione (GSH) and tumor necrosis factor- (TNF-) were assayed. Histopathological study of the substantia nigra was also done. Results: Results showed that rotenone-treated rats exhibited bradykinesia and motor impairment in the open-field test. In addition, GSH level was decreased whereas MDA and TNF- increased in striata of rotenone-treated rats as compared to vehicle-treated rats. Marked degeneration of the substantia nigra pars compacta (SNpc) neurons and depletion of striatal dopamine was also observed in the rotenone-treated rats. Treatment with PIR or VIN significantly reversed the locomotor deficits and increased striatal dopamine level. Treatment with VIN significantly (P < 0.05) reduced the striatal level of MDA and GSH in comparison to rotenone group whereas TNF- production was found to be significantly decreased in PIR group (P < 0.05). Conclusion: VIN and PIR exhibit neuroprotective activity in rotenone-induced Parkinsonism. Hence, these nootropic agents may be considered as possible candidates in the treatment of Parkinsons disease.
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