Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation

Faculty Pharmacy Year: 2015
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Journal: Biology of reproduction Oxford University Press Volume:
Keywords : Deletion , Lysophosphatidic Acid Receptor , (Lpar3) Disrupts    
Abstract:
Deletion of Lpar3 (the third G protein-coupled receptor for lysophosphatidic acid (LPA) leads to an increased ratio of progesterone signaling/estrogen signaling that can be optimized by low doses of RU486 or E2 to restore on-time implantation in knockout females.
    
     
 
       

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