Heterocyclization of a thiouracil derivative as a synthetic entry to novel condensed pyrimidines of biological interest

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages: 869-876
Authors:
Wael Shehta Metwally Elsayed Azab
Journal: Russ. J. Org. Chem, Pleiades Publishing Volume: 56
Keywords : Heterocyclization , , thiouracil derivative , , synthetic entry , novel    
Abstract:
Chlorination of an S-methyl-5-cyano-6-arylthiouracil derivative afforded a chloropyrimidine which underwent aminolysis followed by cyclization to give pyrimidothiazolpyrimidine and imidazopyrimidines. The same thiouracil derivative was also used to prepare oxadiazolopyrimidines, triazolopyrimidines, and pyrimidotriazepines via a diaminopyrimidine and its cyclization with a variety of reagents. Some of the newly synthesized compounds showed a high antibacterial activity against Gram (+ve) and Gram (–ve) bacteria.
    
     
 
       

Author Related Publications

  • Wael Shehta Metwally Elsayed Azab, "Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: Antibacterial activity", SPRINGER, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "Cyclization of mercaptopyrimidine derivative: A facile synthetic approach for condensed pyrimidines", Springer nature, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles", Pleiades Publishing, 2019 More
  • Wael Shehta Metwally Elsayed Azab, "Design and synthesis of fused and spiro pyrazole derivatives", Pleiades Publishing, 2020 More
  • Wael Shehta Metwally Elsayed Azab, "o-Phenylenediamine as a source of fused azole, azine and diazepine derivatives", Pleiades Publishing, 2021 More

Department Related Publications

  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Electronic Properties of Organic Complexes. 2. Reactive Azodyes", Spain, 1993 More
  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Electrical Behaviour of some Azodye Mixed Ligand with Gd3+ and Er3+. b", Peru, 1994 More
  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Haitham Mahmoud Amin Hassan Ashry, ". Electrochemical response of natural and induced passivation of high strength duplex stainless steels in alkaline media", Journal of Solid State Electrochemistry, 2012 More
  • Mohammed Aref Awad Allah Abu Zyd, "Synergistic positive effects of nano barium silicate on the hydration rate and phase composition of alkali-activated slag", Elsevier, 2022 More
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