Heterocyclization of a thiouracil derivative as a synthetic entry to novel condensed pyrimidines of biological interest

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages: 869-876
Authors:
Wael Shehta Metwally Elsayed Azab
Journal: Russ. J. Org. Chem, Pleiades Publishing Volume: 56
Keywords : Heterocyclization , , thiouracil derivative , , synthetic entry , novel    
Abstract:
Chlorination of an S-methyl-5-cyano-6-arylthiouracil derivative afforded a chloropyrimidine which underwent aminolysis followed by cyclization to give pyrimidothiazolpyrimidine and imidazopyrimidines. The same thiouracil derivative was also used to prepare oxadiazolopyrimidines, triazolopyrimidines, and pyrimidotriazepines via a diaminopyrimidine and its cyclization with a variety of reagents. Some of the newly synthesized compounds showed a high antibacterial activity against Gram (+ve) and Gram (–ve) bacteria.
    
     
 
       

Author Related Publications

  • Wael Shehta Metwally Elsayed Azab, "Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: Antibacterial activity", SPRINGER, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "TiO₂ nanocatalyzed synthesis of dihydropyrido[2,3-d]pyrimidine derivatives: A theoretical insight into their antidepressant potentia", Elsiver, 2025 More
  • Wael Shehta Metwally Elsayed Azab, "Synthesis and radiolabelled evaluation of novel pyrimidine derivatives as dual α-amylase inhibitors and GIT-targeted molecular imaging probe", Royal Society of Chemistry, 2025 More
  • Wael Shehta Metwally Elsayed Azab, "Cyclization of mercaptopyrimidine derivative: A facile synthetic approach for condensed pyrimidines", Springer nature, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles", Pleiades Publishing, 2019 More

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