Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages: 806-812
Authors:
Wael Shehta Metwally Elsayed Azab
Journal: Russ. J. Gen. Chem Pleiades Publishing Volume: 89
Keywords : Synthesis , Antibacterial Acivity , Some Novel Pyrimidine-Based    
Abstract:
Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
    
     
 
       

Author Related Publications

  • Wael Shehta Metwally Elsayed Azab, "Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: Antibacterial activity", SPRINGER, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "TiO₂ nanocatalyzed synthesis of dihydropyrido[2,3-d]pyrimidine derivatives: A theoretical insight into their antidepressant potentia", Elsiver, 2025 More
  • Wael Shehta Metwally Elsayed Azab, "Synthesis and radiolabelled evaluation of novel pyrimidine derivatives as dual α-amylase inhibitors and GIT-targeted molecular imaging probe", Royal Society of Chemistry, 2025 More
  • Wael Shehta Metwally Elsayed Azab, "Cyclization of mercaptopyrimidine derivative: A facile synthetic approach for condensed pyrimidines", Springer nature, 2018 More
  • Wael Shehta Metwally Elsayed Azab, "Heterocyclization of a thiouracil derivative as a synthetic entry to novel condensed pyrimidines of biological interest", Pleiades Publishing, 2020 More

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