Background: Recent studies suggested a role of diabetes in regulating the outcome of pulmonary hypertension. Several cytokines are dysregulated in pulmonary hypertension, and were considered accurate predictors of the prognosis. Aim of Study: To evaluate the effects of glycemic control on hemodynamics, metabolic and adipokines (leptin, apelin and adiponectin) levels in patients with pulmonary hypertension and diabetes. Subjects and Methods: Thirty-five pulmonary hypertension patients with diabetes assigned into two groups according to glycosylated hemoglobin (HbA1c) level; tightly controlled group (Group I) (n=20) and conventionally controlled group (Group II) (n=15). Demographic characteristics, hemodynamic assessment, metabolic and serum adipokines levels were assesed. Results: Both groups showed insignificant difference in age, BMI and left ventricular ejection fraction; while mean pulmonary arterial pressure, HbA1c, fasting blood glucose, insulin, HOMA-IR, Cholesterol, triglycerides, Interleukin-6, leptin and apelin were significantly decreased in group I. IL6, leptin and apelin have significant positive correlation with glucose, insulin, HOMA-IR, Cholesterol, TG and MPAP in both groups. Conclusion: Good glycemic control has an impact on hemodynamics, metabolic, inflammatory and adipokine pattern in diabetic patients with pulmonary hypertension, which may affect the progression of the disease. Key Words: Diabetes – Leptin – Apelin – Adiponectin – IL6 – Pulmonary hypertension.