Background: Management of patients with intermediate coronary artery disease by a cost-effective method really has a value to this therapeutic dilemma, especially in patients presented to the catheterization laboratory without prior functional assessment. Methods: A decision model to compare between the cost of FFR-guided coronary interventions and angiographically-guided interventions was done. Intermediate coronary lesions in each patient were assessed twice by using the 2 methods leading to 2 decisions for each patient. A comparison between the costs of the 2 decisions was held. Results: FFR-guided coronary intervention saved 63 stents in 122 lesions in 50 patients. The estimated cost of FFR-guided strategy per patient ranged from LE 25.000 to LE 45.000 with mean value of 26.860+4.500. Whereas the estimated cost of coronary angiography guided strategy per patient ranged from LE 15.000 to LE 61.000 with mean value of 31.740+12.960. Conclusion: Measuring FFR is cost-effective in chronic stable angina especially in diabetic patients with multi-vessel disease.