Background: Bisphenol A (BPA) is a worldwide manufactured chemical in plastic industry. Exposure to BPA through food and drinking water in plastic containers leads to human health problems.Aim of study: This study intends to explore the possible protective role of vitamin E against BPA induced functional and structural changes in the lungs of adult male albino rats. Material and Method: Twenty four adult male albino rats were divided randomly into 4 equal groups of 6 rats each; Group I (controls) ) divided into 2 subgroups: Subgroup (A) (negative control group): fed on regular diet and water for 8 weeks. Subgroup (B) (vehicle control group): received (1 ml of corn oil) by oral gavage/day for 8 weeks. Group II (vitamin E alone) received 200 mg Vitamin E/kg/day; Group III (BPA alone) received 500 mg BPA/kg/day; Group IV (BPA and vitamin E co-administered) as in groups II and III. The drugs were administered through oral gavage for 8 weeks, at the end of the experiment, heart rate (HR) and mean arterial blood pressure (MABP) were estimated for all the animals. Blood samples were withdrawn for chemical examinations, and after sacrifice fresh lung specimens were collected for histological examination. Results: Co-administration of Vitamin E and BPA caused a significant decrease in MABP, HR, malondialdehyde, myeloperoxidase, lactate dehydrogenase (LDH), lung Caspase-3 activities, tumor necrosis factor alpha (TNF-α) and both the interleukins (IL-1β and IL-6). Vitamin E protected lungs against BPA induced histopathological changes like inflammation, congestion, inter alveolar septum thickening, alveolar damage, collagen fibers percent area and fatty infiltration, also the immunohistochemical changes were altered as depicted by significant decrease in the cluster of differentiation 68 (CD68) +ve cell count and decreased expression of nuclear factor kappa B (NF- B) in immunestained cells of the lung tissue. Conclusion: BPA exposure induced oxidative stress, inflammation and structural lung injury which were significantly less by coadminstration of vitamin E supplementation. Keywords: Bisphenol A, oxidative stress, vitamin E, lung.