Fetal asphyxia is defined as depletion of oxygen and accumulation of carbon dioxide leading to hypoxia and acidosis during intrauterine life. The aims of the study were to assess the contributing factors to intrapartum fetal asphyxia and analyze the outcome of intrauterine fetal resuscitation (IUFR) nursing interventions in early versus late onset of intrapartum fetal asphyxia. Study design: Cross sectional observational analytical design. Setting: labor ward of two hospitals (labor and childhood hospital & El- Ahrar hospital). Study subjects: A purposive sample of 220 parturient women in active labor and have fetal asphyxia, divided into two groups: early onset group and late onset group. Tools of data collection: Three main tools: a structured interview questionnaire, contributing factors record and labor & newborn record. Results: Hypertensive disorders of pregnancy and oligohydramnios contributed to 40.9% & 27.7% respectively of the cases of fetal asphyxia. A statistically higher percentages of women who had fetal asphyxia in the transition phase of labor successfully responded to IUFR nursing interventions and delivered vaginally than women who had fetal asphyxia in the active phase of labor (89.0% vs. 75.8% respectively). A statistically higher percentages of newborns in the early onset group had APGAR score <4 at the 1st and 5th minutes and admitted to the NICU than those in the late onset group 15.9%, 9.1%, 14.4% vs. 3.5%, 0.0%, 4.4% respectively. Conclusion: there were many factors that contributed to intrapartum fetal asphyxia mainly hypertensive disorders of pregnancy and oligohydramnios. Moreover, the use of intrapartum IUFR nursing interventions generally decreased the incidence of emergency CS which was done routinely for all cases of intrapartum fetal asphyxia and improved the fetal APGAR score at the 1st and 5th minutes and NICU admissions significantly with late onset of intrapartum fetal asphyxia when delivery was imminent than early onset in the active phase of labor. Recommendations: Maternity nurses should encourage pregnant women to attend scheduled antenatal visits regularly specially in high risk cases in order to control medical and obstetric disorders that contribute to intrapartum fetal asphyxia. Maternity nurses should be trained on the use of IUFR nursing interventions at labor units for category ІІ FHR tracing diagnosed by the on duty physician and emergency CS should be preserved to category ІІІ FHR tracing where the fetal condition is severely compromised. Key words: Fetal asphyxia, Contributing factors, Intrauterine fetal resuscitation.