The research aimed to study the effect of rural knowledge of the sources of pollution of all kinds (water, air, and noise) on the preventive application, and study the effect of rural knowledge of diseases resulting from pollution of all kinds (water, air, and noise) on the preventive application, and the study followed the descriptive analytical approach and the research was conducted with one of Villages of Kafr El-Sheikh Governorate, the village of Al-Ghanameen was chosen randomly, and the study sample reached 100 respondents, whose number was chosen by the appropriate sample according to the nature of the respondents, they were chosen by a random sample method of possession lists in the Agricultural Cooperative Society and to collect the study data was prepared A questionnaire template was collected during the month of September 2019 and was discharged, tabulated and statistically analyzed using the SPSS program. The most important statistical methods are the simple correlation coefficient of Pearson, Alpha cronbach coefficient, Mean, Standard deviation, the multiple regression (Step Wise), and the most important results of the study include the following: A statistically significant effect at the significance level of 0.01 for rural knowledge of pollution sources of all kinds (water, air, and noise) on the preventive application, and a statistically significant effect has been found at the level of 0.01 significance for rural knowledge of diseases caused by pollution of all kinds (water, air) , And noise) on the preventive application. The study recommended that the Ministry of Environment should carry out a campaign to purify the area of the causes of air and water pollutants, and the Ministry of Health should speed up a campaign to treat the villagers from the diseases that spread among the villagers, the most important of which is hepatitis due to the number of injuries in the village .